Dinara Sharipova

RESEARCH INTERESTS  

I am interested in molecular and cellular mechanisms of outflow tract development in zebrafish and, in addition, investigating development of bicuspid aortic valve ­- most common congenital heart defect in humans, using zebrafish as a model organism. I aim to look into morphological variance between different cell types and exploring their interaction at the boundaries between different cell types that share some similar properties (endocardium – endothelium, cardiomyocytes – smooth muscle cells). I am also studying the origin the endocardium and looking for a way to induce endocardial differentiation.

EDUCATION AND RESEARCH EXPERIENCE

2019 – 2021 - Fox Chase Cancer Center, Philadelphia, USA – research internship

“Mechanisms of avapritinib resistance in GIST and new ways of treatment”

2017 – 2019 - Novosibirsk State University, Novosibirsk, Russia - Master of Science (Biology)

“Studying of alpha-synuclein’s interactome in Parkinson’s disease”

2018 - Max Planck Institute of Molecular Cell Biology, Dresden, Germany – research internship

“Flagging down zebrafish transcription factors”

2013 – 2017 - Novosibirsk State University, Novosibirsk, Russia - Bachelor of Science (Biology)

“Generation and characterization of Huntington’s disease cell model using CRISPR/Cas9 system”

PUBLICATIONS

Gehlen J, Stundl A, Debiec R, Fontana F, Krane M, Sharipova D, Nelson CP, Al-Kassou B, Giel AS, Sinning JM, Bruenger CM, Zelck CF, Koebbe LL, Braund PS, Webb TR, Hetherington S, Ensminger S, Fujita B, Mohamed SA, Shrestha M, Krueger H, Siepe M, Kari FA, Nordbeck P, Buravezky L, Kelm M, Veulemans V, Adam M, Baldus S, Laugwitz KL, Haas Y, Karck M, Mehlhorn U, Conzelmann LO, Breitenbach I, Lebherz C, Urbanski P, Kim WK, Kandels J, Ellinghaus D, Nowak-Goettl U, Hoffmann P, Wirth F, Doppler S, Lahm H, Dreßen M, von Scheidt M, Knoll K, Kessler T, Hengstenberg C, Schunkert H, Nickenig G, Nöthen MM, Bolger AP, Abdelilah-Seyfried S, Samani NJ, Erdmann J, Trenkwalder T, Schumacher J. Elucidation of the genetic causes of bicuspid aortic valve disease. Cardiovasc Res. 2022 Jun 21:cvac099. doi: 10.1093/cvr/cvac099. Epub ahead of print. PMID: 35727948.

Kozinova, M.T., Abalakov, G.A., Sharipova, D.V. et al. Molecular-Genetic Basis of Gastrointestinal Stromal Tumor Personalized Therapy by Receptor Tyrosine Kinase Inhibitors (A Review). Pharm Chem J (2021). doi.org/10.1007/s11094-021-02419-8

Kozinova, M.; Joshi, S.; Ye, S.; Belinsky, M.G.; Sharipova, D.; Farma, J.M.; Reddy, S.S.; Litwin, S.; Devarajan, K.; Campos, A.R.; et al. Combined Inhibition of AKT and KIT Restores Expression of Programmed Cell Death 4 (PDCD4) in Gastrointestinal Stromal Tumor. Cancers 2021, 13, 3699. https:// doi.org/10.3390/cancers13153699

Shuai Ye, Dinara Sharipova, Marya Kozinova, Lilli Klug, Jimson D’Souza, Martin G. Belinsky, Katherine J. Johnson, Margret B. Einarson, Karthik Devarajan, Yan Zhou, Samuel Litwin, Michael C. Heinrich, Ronald DeMatteo, Margaret von Mehren, James S. Duncan, Lori Rink. Identification of Wee1 as Target in Combination with Avapritinib for the Treatment of Gastrointestinal Stromal Tumor. JCI Insight, 2021;6(2):e143474. DOI: 10.1172/jci.insight.143474

Sharipova D.V., Bairamova E.M., Kovalenko V.R., Zakian S.M., Medvedev S.P. Generation of transgenic induced pluripotent stem cells for studying molecular and genetic mechanisms of Parkinson’s disease. IN: S.M Zakian, S.P. Medvedev, E.V. Dementyeva, V.V. Vlasov (Eds.), Genes and Genomes Editing. 2020, pp. 379-398. Novosibirsk, Russia: FUE «Publishing house SB RAS» (chapter in a book, in Russian).

D.V. Sharipova, V.R. Kovalenko, E.M. Bairamova, V.A. Vartanova, E.V. Grigor’eva, Y.V. Vyatkin, E.A. Khabarova, D.A. Rzaev, S.M. Zakian, S.P. Medvedev. Generation of two iPSC lines, (ICGi015-A and ICGi015-B), by reprogramming peripheral blood mononuclear cells from a patient with Parkinson's disease. Stem Cell Research 41 (2019). DOI: 10.1016/j.scr.2019.101652

Sharipova D.V., Malankhanova T.B., Malakhova A.A. Huntington’s disease modeling on HEK293 cell line. Vavilovskii Zhurnal Genetiki i Selektsii = Vavilov Journal of Genetics and Breeding. 2017;21 (7):856-­861. DOI 10.18699/ VJ17.306 (in Russian).