Dr. Alessio Paolini

Research Interests

My research interest is to understand the crosstalk between endocardium and myocardium under physiological and pathological conditions. I am also interested in endothelial cell mechanosensation and its contribution to sculpting of the cardiovascular system.

Education

CBTM (Heidelberg University), Mannheim,Germany

Bridging Postdoctoral training, 07-2014/06-2015

Investigating the function of the Wnt/beta-catenin signalling in the establishment of neuroanatomical asymmetries in vivo, using Danio rerio (Zebrafish) as model system.

Heidelberg University, Germany

Ph.D., 02-2010/07-2014

Investigating the molecular and cellular processes underlying the Retinal Ganglion Cells’ differentiation in the vertebrate neural retina, using Danio rerio (Zebrafish) as model system.

University of Pisa, Italy

MSc, 10-2007/07-2009

Characterizing and using the inducible protein Xrx1-GR for the

search of the Xrx1 transcription factor’s direct targets during eye-field specification, using Xenopus laevis as model System

University of Pisa, Italy

BSc, 03-2006/11-2006

Molecular cloning of the inducible construct GR-Xrx1, in the context of the analysis of genes regulated by the transcription factor Xrx1, during the Xenopus laevis eye-field specification

Publications

• Paolini A, Fontana F, Pham VC, Rödel CJ, and Abdelilah-Seyfried S (2021). Mechanosensitive Notch-Dll4 and Klf2-Wnt9 signaling pathways intersect in guiding valvulogenesis in zebrafish. Cell Reports, in press.
• Donat S, Lourenço M, Paolini A, Otten C, Renz M, Abdelilah-Seyfried S (2018). Heg1 and Ccm1/2 proteins control endocardial mechanosensitivity during zebrafish valvulogenesis. ELife 7, e28939 doi: 10.7554.
• Paolini A, Abdelilah-Seyfried S.(2018) The mechanobiology of zebrafish cardiac valve leaflet formation. Curr Opin Cell Biol.11;55:52-58. doi:10.1016/j.ceb.2018.05.007. [Epub ahead of print] Review. PubMed PMID: 30007126.
• Beretta  CA, Dross N, Guglielmi L, Bankhead P, Soulika M, Gutierrez-Triana JA, Paolini A, Poggi L, Falk J, Ryu S, Kapsimali M, Engel U, Carl M (2017) Early Commissural Diencephalic Neurons Control Habenular Axon Extension and Targeting. Current Biology, 27, 270-278.doi:10.1016/j.cub.2016.11.038.
• Paolini A, Duchemin A-L, Albadri S, Patzel E, Bornhorst D, Gonzalez PA, Lemke S, Machate A, Brand M, Sel S, Di Donato V, Del Bene F, Zolessi FR, Ramialison M and Poggi L (2015) Asymmetric inheritance of the apical domain and self-renewal of retinal ganglion cell progenitors depend on Anillin function. Developmentdoi: 10.1242/dev.118612
• Hüsken U, Stickney HL, Gestri G, Bianco IH, Faro A, Young RM, Roussigne M, Hawkins TA, Beretta CA, Brinkmann I, Paolini A, Jacinto R, Albadri S, Dreosti E, Tsalavouta M, Schwarz Q, Cavodeassi F, Barth AK, Wen L, Zhang B, Blader P, Yaksi E, Poggi L, Zigman M, Lin S, Wilson SW and Carl M (2014) Tcf7l2 is required for left-right asymmetric differentiation of habenular neurons. Current Biologydoi: 10.1016/j.cub.2014.08.006.
• Mwafi N, Beretta CA, Paolini A, Carl M (2014) Divergent Wnt8a Gene Expression in Teleosts. PLoS ONE 9(1): e85303doi:10.1371/journal.pone.0085303
• Jusuf PR, Albadri S, Paolini A, Currie PD, Argenton F, Higashijima SI, Harris WA, Poggi L. (2012) Biasing Amacrine Subtypes in the Atoh7 Lineage through Expression of Barhl2. Journal of Neuroscience, 32(40), 13929–13944. doi:10.1523/JNEUROSCI.2073-12.2012