Van-Cuong Pham

RESEARCH INTERESTS

As an early stage researcher of the MSCA Innovative Training Network V. A. Cure, which aims to discover mechanisms and better treatment for Vascular Anomalies, my research interest lies on the vascular disease Cerebral Cavernous Malformation (CCM). I am investigating CCM pathogenesis by using zebrafish as animal model with genetic approaches.

EDUCATION

Master of Science, 2019

Kyushu University, Japan

“Physiological and cellular stress responses of goldfish (Carassius auratus) to acute and chronic high-water temperature”

Bachelor of Science, 2015

University of Science, Vietnam National University-Hanoi, Vietnam

“Generation of homozygous rankl:HSE:CFP transgenic medaka fish for use as an osteoporosis model”

PUBLICATIONS

• Pham VC^#, Rödel CJ^#, Valentino M, Malinverno M, Paolini A, Münch J, Pasquier C, Onyeogarizi F, Lazovic B, Girard R, Koskimäki J, Hußmann M, Keith B, Jachimowicz D, Kohl F, Hagelkruys A, Penninger J, Schulte-Merker S, Awad I, Hicks R, Magnusson PU, Faurobert E, Pagani M*, Abdelilah-Seyfried S Epigenetic regulation by polycomb repressive complex 1 promotes cerebral cavernous malformations. EMBO Mol. Med. (2024) doi: 10.1038/s44321-024-00152-9. (^#contributed equally)
• Valentino M, Malinverno M, Maderna C, Pham VC, Rödel CJ, Zanardi F, Arce M, Drufuca L, Rossetti G, Magnusson PU, Lampugnani MG, Dejana E, Abdelilah-Seyfried S, Pagani M. BMI1 Inhibition Improves Lesion Burden in Cerebral Cavernous Malformations. Circulation (2024). doi: 10.1161/CIRCULATIONAHA.123.067438.
• Bortoli MD, Queisser A, Pham VC, Dompmartin A, Helaers R, Boutry S, Claus C, Roo AKD, Hammer F, Brouillard P, Abdelilah-Seyfried S, Boon LM, Vikkula M. Somatic Loss-of-Function PIK3R1 and Activating Non-hotspot PIK3CA Mutations Associated with Capillary Malformation with Dilated Veins (CMDV). J Invest Dermatol (2024). doi: 10.1016/j.jid.2024.01.033.
• Paolini A, Fontana F, Pham VC, Rödel CJ, Abdelilah-Seyfried S. Mechanosensitive Notch-Dll4 and Klf2-Wnt9 signaling pathways intersect in guiding valvulogenesis in zebrafish. Cell Rep (2021). doi: 10.1016/j.celrep.2021.109782.
• Tran PV, Tamura Y, Pham CV, Elhussiny MZ, Han G, Chowdhury VS, Furuse M. Neuropeptide Y modifies a part of diencephalic catecholamine but not indolamine metabolism in chicks depending on feeding status. Neuropeptides (2021). doi: 10.1016/j.npep.2021.102169.
• Elhussiny MZ, Tran PV, Pham CV, Nguyen LTN, Haraguchi S, Gilbert ER, Cline MA, Bungo T, Furuse M, Chowdhury VS. Central GABAA receptor mediates taurine-induced hypothermia and possibly reduces food intake in thermo-neutral chicks and regulates plasma metabolites in heat-exposed chicks. J Therm Biol (2021). doi: 10.1016/j.jtherbio.2021.102905.
• Wang Y, Han G, Pham CV, Koyanagi K, Song Y, Sudo R, Lauwereyns J, Cockrem JF, Furuse M. An acute increase in water temperature can increase free amino acid concentrations in the blood, brain, liver, and muscle in goldfish (Carassius auratus). Fish Physiol Biochem (2019). doi: 10.1007/s10695-019-00642-5.
• Pham VC, Pham TT, Lai TT, Trinh CD, Nguyen VMH, Ha TMT, Phuong TT, Tran DL, Winkler C, To TT. Icariin reduces bone loss in a Rankl-induced transgenic medaka (Oryzias latipes) model for osteoporosis. J Fish Biol (2019) .doi: 10.1111/jfb.14241