Ultrafast Structural Dynamics - Watching Molecules in Action
The group of Henrike Müller-Werkmeister is working on ultrafast structural dynamics in chemical and biochemical systems. Our research aims to "film molecules in action".
We focus on timescales starting in the femtosecond regime and picosecond regime, with occasional experiments up to seconds and longer. Experimentally, we mainly use spectroscopic approaches, in particular 2D-IR spectroscopy, which is inherently structure-sensitive. In addition to 2D-IR spectroscopy, we are involved into other structural dynamics experiments, primarily utilizing X-rays as structural probes in time-resolved crystallography and electron density experiments.
Our interest focuses on the fundamentals of reaction dynamics (i.e. photochemistry, a very useful tool for time-resolved crystallography etc.), vibrational energy transfer, spin-crossover dynamics and structural rearrangements like bond-breaking events and how these fast processes connect to phenomena on longer timescales, with particular emphasis on protein dynamics, allostery and structure function correlation. All of our scientific questions are driven by the curiosity to understand the physicochemical basis of biological processes using advanced experimental tools.
Our main technique is 2D-IR spectroscopy (in the lab in Golm) and we use and advance time-resolved crystallography methods at advanced light sources (mainly beamtimes at Petra III/DESY, European XFEL and ELI).
We would love you to join us in this adventurous research at the intersection of physics, chemistry and biochemistry.