Peer-Reviewed Articles
2023
Y. Bengtsson, K. Demircan, J. Vallon-Christersson, M. Malmberg, L. H. Saal, L. Rydén, Å. Borg, L. Schomburg, M. Sandsveden, J. Manjer
Serum copper, zinc and copper/zinc ratio in relation to survival after breast cancer diagnosis: A prospective multicenter cohort study
Redox Biol. 2023; 63:102728. doi: 10.1016/j.redox.2023.102728
N. Karavasiloglou, D. J. Hughes, N. Murphy, L. Schomburg, Q. Sun, V. Seher, S. Rohrmann, E. Weiderpass, A. Tjønneland, A. Olsen, K. Overvad, M. C. Boutron-Ruault, F. R. Mancini, Y. Mahamat-Saleh, R. Kaaks, T. Kuhn, M. B. Schulze, R. Tumino, S. Panico, G. Masala, V. Pala, C. Sacerdote, J. W. G. Derksen, G. Skeie, A. Hjartåker, C. Lasheras, A. Agudo, M. J. Sánchez, M. D. Chirlaque, E. Ardanaz, P. Amiano, B. Van Guelpen, B. Gylling, K. E. Bradbury, K. Papier, H. Freisling, E. K. Aglago, A. J. Cross, E. Riboli, D. Aune, M. J. Gunter, M. Jenab
Prediagnostic serum calcium concentrations and risk of colorectal cancer development in 2 large European prospective cohorts
Am J Clin Nutr. 2023; 117(1):33-45. doi: 10.1016/j.ajcnut.2022.10.004
C. Stoppe, B. McDonald, P. Meybohm, K. B. Christopher, S. Fremes, R. Whitlock, S. Mohammadi, D. Kalavrouziotis, G. Elke, R. Rossaint, P. Helmer, K. Zacharowski, U. Günther, M. Parotto, B. Niemann, A. Böning, C. D. Mazer, P. M. Jones, M. Ferner, Y. Lamarche, F. Lamontagne, O. J. Liakopoulos, M. Cameron, M. Müller, A. Zarbock, M. Wittmann, A. Goetzenich, E. Kilger, L. Schomburg, A. G. Day, D. K. Heyland; SUSTAIN CSX Study Collaborators
Effect of High-Dose Selenium on Postoperative Organ Dysfunction and Mortality in Cardiac Surgery Patients: The SUSTAIN CSX Randomized Clinical Trial
JAMA Surg. 2023; 158(3): 235-244. doi: 10.1001/jamasurg.2022.6855.
C. Dame, D. Horn, L. Schomburg, J. Grünhagen, T. S. Chillon, A. Tietze, A. Vogt, C. Bührer
Fatal congenital copper transport defect caused by a homozygous likely pathogenic variant of SLC31A1
Clin Genet.; 2023; 103(5):585-589. doi: 10.1111/cge.14289.
J. Hackler, K. Demircan, T. S. Chillon, Q. Sun, N. Geisler, M. Schupp, K. Renko, L. Schomburg
High throughput drug screening identifies resveratrol as suppressor of hepatic SELENOP expression
L. Redox Biol.; 2023; 59: 102592. doi: 10.1016/j.redox.2022.102592
M. Schwarz, C. E. Meyer, A. Löser, K. Lossow, J. Hackler, Ch. Ott, S. Jäger, I. Mohr, E. A. Eklund, A. A. H. Patel, N. Gul, S. Alvarez, I. Altinonder, C. Wiel,
M. Maares, H. Haase, A. Härtlova, T. Grune, M. B. Schulze, T. Schwerdtle, U. Merle, H. Zischka, V. I. Sayin, L. Schomburg, A. P. Kipp
Excessive copper impairs intrahepatocyte trafficking and secretion of selenoprotein P
Nature Communications; 14 (2023) 3479. doi: 10.1038/s41467-023-39245-3
M. Schwarz, A. Löser, Q. Cheng, M. Wichmann-Costaganna, P. Schädel, O. Werz, E. SJ. Arnér, A. P. Kipp
Side-by-side comparison of recombinant human glutathione peroxidases identifies overlapping substrate specificities for soluble hydroperoxides
Redox Biology; 59 (2023) 102593. doi: 10.1016/j.redox.2022.102593
K. Lossow, W. Schlörmann, M. Tuchtenhagen, M. Schwarz, T. Schwerdtle, A. P. Kipp
Measurement of trace elements in murine liver tissue samples: Comparison between ICP-MS/MS and TXRF
Journal of Trace Elements in Medicine and Biology; 78 (2023) 127167. doi: 10.1016/j.jtemb.2023.127167
S. Raschke, F. Ebert, A. P. Kipp, J. F. Kopp, T. Schwerdtle
Selenium homeostasis in human brain cells: Effects of copper (II) and Se species
Journal of Trace Elements in Medicine and Biology; 78 (2023) 127149. doi: 10.1016/j.jtemb.2023.127149
A. Thiel, A.-K. Weishaupt, M. M. Nicolai, K. Lossow, A. P. Kipp, T. Schwerdtle, J. Bornhorst
Simultaneous quantitation of oxidized and reduced glutathione via LC-MS/MS to study the redox state and drug-mediated modulation in cells, worms and animal tissue
Journal of Chromatography; B 1225 (2023) 123742. doi: 10.1016/j.jchromb.2023.123742
2022
K. Demircan, T. S. Chillon, T. Bracken, I. Bulgarelli, I. Campi, G. Du Laing, S. Fafi-Kremer, L. Fugazzola, A. A. Garcia, R. Heller, D. J. Hughes, L. Ide, G. J. Klingenberg, P. Komarnicki, Z. Krasinski, A. Lescure, P. Mallon, A. Moghaddam, L. Persani, M. Petrovic, M. Ruchala, M. Solis, L. Vandekerckhove, L. Schomburg
Association of COVID-19 mortality with serum selenium, zinc and copper: Six observational studies across Europe
Front Immunol.; 2022; 13:1022673. doi: 10.3389/fimmu.2022.1022673. eCollection 2022.PMID: 36518764 Free PMC article.
R. Hauffe , M. Rath, W. Agyapong, W. Jonas, H. Vogel, T. J. Schulz, M. Schwarz, A. P. Kipp, M. Blüher, A. Kleinridders
Obesity Hinders the Protective Effect of Selenite Supplementation on Insulin Signaling
Antioxidants; 2022, 11, 862. doi: 10.3390/antiox11050862
M. Maares, C. Keil, L. Pallasdies, M. Schmacht, M. Senz, J. Nissen, H. Kieserling, St. Drusch, H. Haase
Zinc availability from zinc-enriched yeast studied with an in vitro digestion / Caco-2 cell culture model
Journal of Trace Elements in Medicine and Biology 2022; 71 (2022) 126934. doi: 10.1016/j.jtemb.2022.126934
M. Maares, J. Hackler, A. Haupt, R. A. Heller, M. Bachmann, J. Diegmann, A. Moghaddam, L. Schomburg, H. Haase
Free Zinc as a Predictive Marker for COVID-19 Mortality Risk
Nutrients 2022; 14 (7), 1407. doi: 10.3390/nu14071407
Schomburg L.
Selenoprotein P - Selenium transport protein, enzyme and biomarker of selenium status.
Free Radic Biol Med. 2022; 191: 150-163. doi: 10.1016/j.freeradbiomed.2022.08.022. Epub 2022 Sep 5. PMID: 36067902 Review.
U. Schweizer, E. K. Wirth, Th. Klopstock, S. M. Hölter, L. Becker, J. Moskovitz, T. Grune, H. Fuchs, V. Gailus-Durner, M. Hrabe de Angelis, J. Köhrle,
L. Schomburg
Seizures, ataxia and parvalbumin-expressing interneurons respond to selenium supply in Selenop-deficient mice.
Redox Biol. 2022; 57: 102490. doi: 10.1016/j.redox.2022.102490 Online ahead of print.PMID: 36182809 Free PMC article.
D. Filipowicz, E. Szczepanek-Parulska, M. Kłobus, K. Szymanowski, T. S. Chillon, S. Asaad, Q. Sun, A. A. Mikulska-Sauermann, M. Karaźniewicz-Łada, F. K. Główka, D. Wietrzyk, L. Schomburg, M. Ruchała
Selenium Status and Supplementation Effects in Pregnancy-A Study on Mother-Child Pairs from a Single-Center Cohort.
Nutrients. 2022; 14 (15): 3082. doi: 10.3390/nu14153082.
J. Kryczyk-Kozioł, E. Prochownik, A. Błażewska-Gruszczyk, M. Słowiaczek, Q. Sun, L. Schomburg, E. Ochab, M. Bartyzel, Zagrodzki P
Assessment of the Effect of Selenium Supplementation on Production of Selected Cytokines in Women with Hashimoto's Thyroiditis.
Nutrients. 2022; 14 (14): 2869. doi: 10.3390/nu14142869.
Q. Wu, Y. Wang, P. Chen, J. Wei, H. Lv, S. Wang, Y. Wu, X. Zhao, X. Peng, E. Rijntjes, Y. Wang, L. Schomburg, B. Shi
Increased incidence of Hashimoto's thyroiditis in selenium deficiency: a prospective six-year cohort study.
J Clin Endocrinol Metab. 2022: dgac410. doi: 10.1210/clinem/dgac410
T. S. Chillon, M. Maares, K. Demircan, J. Hackler, Q. Sun, R. A. Heller, J. Diegmann, M. Bachmann, A. Moghaddam, H. Haase, L. Schomburg
Serum Free Zinc Is Associated With Vaccination Response to SARS-CoV-2.
Front Immunol. 2022; 13: 906551. doi: 10.3389/fimmu.2022.906551
C. L. Görlich, Q. Sun, V. Roggenkamp, J. Hackler, S. Mehl, W. B. Minich, A. M. Kaindl, L. Schomburg
Selenium Status in Paediatric Patients with Neurodevelopmental Diseases.
Nutrients. 2022; 14 (12): 2375. doi: 10.3390/nu14122375
K. Demircan, Q. Sun, Y. Bengtsson, P. Seemann, J. Vallon-Christersson, M. Malmberg, L. H. Saal, L. Rydén, W. B. Minich, Å. Borg, J. Manjer, L. Schomburg
Autoimmunity to selenoprotein P predicts breast cancer recurrence.
Redox Biol. 2022; 53: 102346. doi: 10.1016/j.redox.2022
O. M. Ijomone, J. D. Iroegbu, P. Morcillo, A. J. Ayodele, O. K. Ijomone, J. Bornhorst, T. Schwerdtle, M. Aschner
Sex-dependent metal accumulation and immunoexpression of Hsp70 and Nrf2 in rats' brain following manganese exposure.
Environ Toxicol. 2022. doi: 10.1002/tox.23583
K. Demircan, T.S. Chillon, Q. Sun, R. A. Heller, G. J. Klingenberg, I. M. Hirschbil-Bremer, P. Seemann, J. Diegmann, M. Bachmann, A. Moghaddam, L. Schomburg
Humoral immune response to COVID-19 mRNA vaccination in relation to selenium status.
Redox Biol. 2022; 50: 102242. doi: 10.1016/j.redox.2022.102242
L. Schomburg
Selenium Deficiency in COVID-19-A Possible Long-Lasting Toxic Relationship.
Nutrients. 2022; 14 (2): 283. doi: 10.3390/nu14020283
M. W. Pitts, P. R. Hoffmann, L. Schomburg
Editorial: Selenium and Selenoproteins in Brain Development, Function, and Disease.
Front Neurosci. 2022. doi: 10.3389/fnins.2021.821140
M. M. Nicolai, B. Witt , S. Friese, V. Michaelis, L. Hölz-Armstrong, M. Martin, F. Ebert, T. Schwerdtle, J. Bornhorst
Mechanistic studies on the adverse effects of manganese overexposure in differentiated LUHMES cells.
Food and Chemical Toxicology. 2022. doi: 10.1016/j.fct.2022.112822
2021
K. Lossow, K. Renko, M. Schwarz, L. Schomburg, T. Schwerdtle, A. P. Kipp
The Nutritional Supply of Iodine and Selenium Affects Thyroid Hormone Axis Related Endpoints in Mice.
Nutrients. 2021; 13 (11): 3773. doi: 10.3390/nu13113773
K. Lossow, M. Schwarz, A. P. Kipp
Are trace element concentrations suitable biomarkers for the diagnosis of cancer?
Redox Biol. 2021; 42: 101900. doi: 10.1016/j.redox.2021.101900
J. R. Baker, S. Umesh, M. Jenab, L. Schomburg, A. Tjønneland, A. Olsen, M. C. Boutron-Ruault, J. A. Rothwell, G. Severi, V. Katzke, T. Johnson, M. B. Schulze, G. Masala, C. Agnoli, V. Simeon, R. Tumino, H. B. Bueno-de-Mesquita, I. T. Gram, G. Skeie, C. Bonet, M. Rodriguez-Barranco, J. M. Houerta, B. Gylling, B. Van Guelpen, A. Perez-Cornago, E. Aglago, H. Freisling, E. Weiderpass, A. J. Cross, A. K. Heath, D. J. Hughes, V. Fedirko
Prediagnostic Blood Selenium Status and Mortality among Patients with Colorectal Cancer in Western European Populations.
Biomedicines. 2021; 9 (11): 1521. doi: 10.3390/biomedicines9111521
L. J. Schmalbrock, G. Weiss, E. Rijntjes, N. Reinschissler, Q. Sun, M. Schenk, L. Schomburg
Pronounced Trace Element Variation in Follicular Fluids of Subfertile Women Undergoing Assisted Reproduction.
Nutrients. 2021; 13(11): 4134. doi: 10.3390/nu13114134
Q. Sun, S. Mehl, K. Renko, P. Seemann, C. L. Görlich, J. Hackler, W. B. Minich, G. J. Kahaly, L. Schomburg
Natural Autoimmunity to Selenoprotein P Impairs Selenium Transport in Hashimoto's Thyroiditis.
Int J Mol Sci. 2021; 22 (23): 13088. doi: 10.3390/ijms222313088
E. Laaf, C. Benstoem, R. Rossaint, S. Wendt, Ch. Fitzner, A. Moza, R. Zayat, A. Hill, D. K Heyland, L. Schomburg, A. Goetzenich, Ch. Stoppe
High-dose supplementation of selenium in left ventricular assist device implant surgery: A double-blinded, randomized controlled pilot trial.
JPEN J Parenter Enteral Nutr. 2021. doi: 10.1002/jpen.2309
N. Crawford, M. Martell, T. Nielsen, B. Khalil, F. Imtiaz, E. Nguidjo, J. L. Newell-Caito, J. Bornhorst, T. Schwerdtle, S. W. Caito
Methylmercury-Induced Metabolic Alterations in Caenorhabditis elegans Are Diet-Dependent.
Toxics 2021, 9 (11), 287. doi: 2305-6304/9/11/287
M. M. Nicolai, A. K. Weishaupt, J. Baesler, V. Brinkmann, A. Wellenberg, N. Winkelbeiner, A. Gremme, M. Aschner, G. Fritz, T. Schwerdtle, J. Bornhorst
Effects of Manganese on Genomic Integrity in the Multicellular Model Organism Caenorhabditis elegans.
Int. J. Mol. Sci. 2021, 22, 10905. doi: 10.3390/ijms222010905
J. Scholz, P. O. Helmer, M. M. Nicolai, J. Bornhorst, H. Hayen
Profiling of sphingolipids in Caenorhabditis elegans by two-dimensional multiple heart-cut liquid chromatography – mass spectrometry.
J Chromatogr A.; Oct 2021; 1655:462481. doi: 10.1016/j.chroma.2021.462481
G. Du Laing, M. Petrovic, C. Lachat, M. De Boevre, G. J. Klingenberg, Q. Sun, S. De Saeger, J. De Clercq, L. Ide, L. Vandekerckhove, L. Schomburg
Course and Survival of COVID-19 Patients with Comorbidities in Relation to the Trace Element Status at Hospital Admission.
Nutrients 2021, 13, 3304. doi: 10.3390/nu13103304
L. S. Kazi Tani, A. T. Gourlan, N. Dennouni-Medjati, P. Telouk, M. Dali-Sahi, Y. Harek, Q. Sun, J. Hackler, M. Belhadj, L. Schomburg, L. Charlet
Copper Isotopes and Copper to Zinc Ratio as Possible Biomarkers for Thyroid Cancer.
Front Med (Lausanne); Sep 2021. 8:698167, doi: 10.3389/fmed.2021.698167
K. Demircan, Y. Bengtsson, Q. Sun, A. Brange, J. Vallon-Christersson, E. Rijntjes, M. Malmberg, L. H. Saal, L. Rydén, Å. Borg, J. Manjer, L. Schomburg
Serum selenium, selenoprotein P and glutathione peroxidase 3 as predictors of mortality and recurrence following breast cancer diagnosis: A multicentre cohort study.
Redox Biol.; Sep 2021; 47: 102145. doi: 10.1016/j.redox.2021.102145
J. Kryczyk-Kozioł, P. Zagrodzki, E. Prochownik, A. Błażewska-Gruszczyk, M. Słowiaczek, Q. Sun, L. Schomburg, E. Ochab, M. Bartyzel
Positive effects of selenium supplementation in women with newly diagnosed Hashimoto's thyroiditis in an area with low selenium status.
Int J Clin Pract.; Sep 2021; 75(9): e14484. doi: 10.1111/ijcp.14484
S. Jäger, M. Cabral, J. F. Kopp, P. Hoffmann, E. Ng, J. B. Whitfield, A. P. Morris, L. Lind, T. Schwerdtle, M. B. Schulze
Blood copper and risk of cardiometabolic diseases-A Mendelian randomization study.
Human Molecular Genetics; Sep 2021; ddab275. doi: 10.1093/hmg/ddab275
L. Schomburg
Selenium Deficiency Due to Diet, Pregnancy, Severe Illness, or COVID-19-A Preventable Trigger for Autoimmune Disease.
Int J Mol Sci.; Aug 2021; 22 (16): 8532. doi: 10.3390/ijms22168532
M. M. Nicolai, B. Witt, A. Hartwig, T. Schwerdtle, J. Bornhorst
A fast and reliable method for monitoring genomic instability in the model organism Caenorhabditis elegans.
Arch Toxicol; 2021. doi: 10.1007/s00204-021-03144-7
V. Wandt, N. Winkelbeiner, K. Lossow, J. F. Kopp, M. Schwarz, W. Alker, M. M. Nicolai, L. Simon, C. Dietzel, B. Hertel, G. Pohl, F. Ebert, L. Schomburg, J. Bornhorst, H. Haase, A. P. Kipp, T. Schwerdtle
Ageing-associated effects of a long-term dietary modulation of four trace elements in mice.
Redox Biol.; Jul 2021; 46:102083. doi: 10.1016/j.redox.2021.102083
Q. Notz, J. Herrmann, T. Schlesinger, P. Helmer, S. Sudowe, Q. Sun, J. Hackler, D. Roeder, C. Lotz, P. Meybohm, P. Kranke, L. Schomburg, C. Stoppe C.
Clinical Significance of Micronutrient Supplementation in Critically Ill COVID-19 Patients with Severe ARDS.
Nutrients; Jun 2021 ;13 (6):2113. doi: 10.3390/nu13062113
J. Seelig, R. A. Heller, P. Haubruck, Q. Sun, G. J. Klingenberg, J. Hackler, H. L. Crowell, V. Daniel, A. Moghaddam, L. Schomburg and B. Biglari
Selenium-Binding Protein (SELENBP1) as Biomarker for Adverse Clinical Outcome After Traumatic Spinal Cord Injury.
Front. Neurosci.; 15:680240; May 2021. doi: 10.3389/fnins.2021.680240
J. Hackler, R. A. Heller, Q. Sun, M. Schwarzer, J. Diegmann, M. Bachmann, A. Moghaddam, L. Schomburg
Relation of Serum Copper Status to Survival in COVID-19.
Nutrients; 2021, 13, 1898. doi: 10.3390/nu13061898
T. Porst, J. Johannes, H. Gluschke, R. Köhler, S. Mehl, P. Kühnen, K. Renko, W. B. Minich, S. Wiegand, L. Schomburg
Natural Autoimmunity to the Thyroid Hormone Monocarboxylate Transporters MCT8 and MCT10.
Biomedicines; Apr 2021; 9(5): 496. doi: 10.3390/biomedicines9050496.
L. M. Sattler, H.A. Schniewind, W. B. Minich, C. W. Haudum, P. Niklowitz, J. Münzker, G. L. Kovács, T. Reinehr, B. Obermayer-Pietsch, L. Schomburg
Natural autoantibodies to the gonadotropin-releasing hormone receptor in polycystic ovarian syndrome.
PLoS One; Apr 2021;16(4): e0249639. doi: 10.1371/journal.pone.0249639
S. Gül-Klein, D. Haxhiraj, J. Seelig, A. Kästner, J. Hackler, Q. Sun, R. A. Heller, N. Lachmann, J. Pratschke, M. Schmelzle, L. Schomburg
Serum Selenium Status as a Diagnostic Marker for the Prognosis of Liver Transplantation.
Nutrients; Feb 2021;13(2): 619. doi: 10.3390/nu13020619
N. Seiwert, J. Adam, P. Steinberg, St. Wirtz, T. Schwerdtle, P. Adams-Quack, N. Hövelmeyer, B. Kaina, S. Foersch, J. Fahrer
Chronic intestinal inflammation drives colorectal tumor formation triggered by dietary heme iron in vivo.
Arch Toxicol 2021. doi: 10.1007/s00204-021-03064-6
J. Baesler, V. Michaelis, M. Stiboller, H. Haase, M. Aschner, T. Schwerdtle, S. R. Sturzenbaum, J. Bornhorst
Nutritive manganese and zinc overdosing in aging C. elegans result in a metallothionein-mediated alteration in metal homeostasis.
Mol Nutr Food Res.; Feb 2021; e2001176. doi: 10.1002/mnfr.202001176
V. K. Wandt, N. Winkelbeiner, J. Bornhorst, B. Witt, S. Raschke, L. Simon, F. Ebert, A. P. Kipp, T. Schwerdtle
A matter of concern - Trace element dyshomeostasis and genomic stability in neurons.
Redox Biology 2021; 41 (101877); 2213-2217. doi: 10.1016/j.redox.2021.101877
J. Menzel, K. Abraham, G. I. Stangl, P. Magne Ueland, R. Obeid, M. B. Schulze, I. Herter-Aeberli, T. Schwerdtle, C. Weikert
Vegan diet and bone health - Results from the cross-sectional RBVD study.
Nutrients 2021; 13 (2); 685. doi: 10.3390/nu13020685
M. Cabral, O. Kuxhaus, F. Eichelmann, J. F. Kopp, W. Alker, J. Hackler, A. P. Kipp, T. Schwerdtle, H. Haase, L. Schomburg, M. B. Schulze
Trace element profile and incidence of type 2 diabetes, cardiovascular disease and colorectal cancer: results from the EPIC-Potsdam cohort study.
European Journal of Nutrition 2021 [accepted]. doi: 10.1007/s00394-021-02494-3
2020
M. Maares, H. Haase
A Guide to Human Zinc Absorption: General Overview and Recent Advances of In Vitro Intestinal Models
Nutrients 2020, 12 (3), 762. https://doi.org/10.3390/nu12030762
M. Maares, C. Keil, S. Straubing, C. Robbe-Masselot, H. Haase
Zinc Deficiency Disturbs Mucin Expression, O-Glycosylation and Secretion by Intestinal Goblet Cells
Int. J. Mol. Sci. 2020, 21, 6149. https://doi.org/10.3390/ijms21176149
R. A. Heller, Q. Sun, J. Hackler, J. Seelig, L. Seibert, A. Cherkezov, W. B. Minich, P. Seemann, J. Diegmann, M. Pilz, M. Bachmann, A. Ranjbar, A. Moghaddam,L. Schomburg
Prediction of survival odds in COVID-19 by zinc, age and selenoprotein P as composite biomarker.
Redox Biol. 2020; Oct. 2020; 38: 101764. doi: 10.1016/j.redox.2020.101764
M. Belhadj, L. S. Kazi Tani, N. Dennouni Medjati, Y. Harek, M. Dali Sahi, Q. Sun, R. Heller, A. Behar, L. Charlet, L.Schomburg
Se Status Prediction by Food Intake as Compared to Circulating Biomarkers in a West Algerian Population.
Nutrients 2020; Nov. 2020; 12 (12): E3599. doi: 10.3390/nu12123599
T. Wolfram, M. Schwarz, M. Reuß, K. Lossow, M. Ost, S. Klaus,T. Schwerdtle, A. P. Kipp
N-Acetylcysteine as Modulator of the Essential Trace Elements Copper and Zinc.
Antioxidants 2020; Nov. 2020; 9 (11), 1117. doi: 10.3390/antiox9111117
M. Schwarz, K. Lossow, K. Schirl, J. Hackler, J. F. Kopp, K. Renko, T. Schwerdtle, L. Schomburg, A. P. Kipp
Copper interferes with selenoprotein synthesis and activity.
Redox Biol.; Oct. 2020. doi: 10.1016/j.redox.2020.101746
N. Winkelbeiner, V. K. Wandt, F. Ebert, K. Lossow, E. E. Bankoglu, M. Martin, A. Mangerich, H. Stopper, J. Bornhorst, A. P. Kipp, T. Schwerdtle
A Multi-Endpoint Approach to Base Excision Repair Incision Activity Augmented by PARylation and DNA Damage Levels in Mice: Impact of Sex and Age.
Int. J. Mol. Sci.; Sep 2020; 21, 6600. doi: 10.3390/ijms21186600
Y. Wang, E. Rijntjes, Q. Wu, H. Lv, C. Gao, B. Shi, L. Schomburg
Selenium deficiency is linearly associated with hypoglycemia in healthy adults.
Redox Biol.; Sep 2020; 37: 101709. doi: 10.1016/j.redox.2020.101709
M. Outzen, A. Tjønneland, DJ Hughes, M. Jenab, K. Frederiksen, L. Schomburg, S. Morris, K. Overvad, A. Olsen
Toenail selenium, plasma selenoprotein P and risk of advanced prostate cancer: A nested case-control study.
INT J CANCER; Aug 2020. doi: 10.1002/ijc.33267
H. Finke, N. Winkelbeiner, K. Lossow, B. Hertel, V. K. Wandt, M. Schwarz, G. Pohl, J. F. Kopp, F. Ebert, A. P. Kipp, T. Schwerdtle
Effects of a Cumulative, Suboptimal Supply of Multiple Trace Elements in Mice: Trace Element Status, Genomic Stability, Inflammation, and Epigenetics.
Mol. Nutr. Food Res.; July 2020; 64, 2000325. doi: 10.1002/mnfr.202000325
A. Moghaddam, RA Heller, Q. Sun, J. Seelig, A. Cherkezov, L. Seibert, J. Hackler, P. Seemann, J. Diegmann, M. Pilz, M. Bachmann, WB Minich, L. Schomburg
Selenium Deficiency Is Associated with Mortality Risk from COVID-19.
Nutrients; July 2020; 12 (7): 2098. doi: 10.3390/nu12072098
Q. Sun, J. Hackler, J. Hilger, H. Gluschke, A. Muric, S. Simmons, L. Schomburg, E. Siegert
Selenium and Copper as Biomarkers for Pulmonary Arterial Hypertension in Systemic Sclerosis.
Nutrients; June 2020;12 (6): 1894. doi: 10.3390/nu12061894.
K. Lossow, J.F. Kopp, M. Schwarz, H. Finke , N. Winkelbeiner , K. Renko , X. Meçi , Ch. Ott , W. Alker , J. Hackler, T. Grune, L. Schomburg, H. Haase, T. Schwerdtle, A. P. Kipp
Aging affects sex- and organ-specific trace element profiles in mice.
AgING; July 2020. doi: 10.18632/aging.103572
H. Finke, V. K. Wandt, F. Ebert, N. Guttenberger, R. A. Glabonjat, M. Stiboller, K. A. Francesconi, G. Raber, T. Schwerdtle
Toxicological assessment of arsenic-containing phosphatidylcholines in HepG2 cells.
Metallomics; May 2020. doi: 10.1039/D0MT00073F
R. Hauffe, V. Stein, Ch. Chudoba, T. Flore, M. Rath, K. Ritter, M. Schell, K. Wardelmann, S. Deubel, J. F. Kopp, M. Schwarz, K. Kappert, M. Blüher, T. Schwerdtle, A. P. Kipp, A.Kleinridders
GPx3 dysregulation impacts adipose tissue insulin receptor expression and sensitivity.
JCI insight; May 2020; 5(11):e136283. doi: 10.1172/jci.insight.136283
R.A. Heller, A. Sperl, J. Seelig, P. Haubruck, T. Bock, T. Werner, A. Besseling, Q. Sun, L. Schomburg, A. Moghaddam, B. Biglari.
Zinc Concentration Dynamics Indicate Neurological Impairment Odds after Traumatic Spinal Cord Injury.
Antioxidants (Basel); May 2020; 9(5):421. doi: 10.3390/antiox9050421
O. Brodin, J. Hackler, S. Misra, S. Wendt, Q. Sun, E. Laaf, C. Stoppe, M. Björnstedt, L. Schomburg.
Selenoprotein P as Biomarker of Selenium Status in Clinical Trials with Therapeutic Dosages of Selenite.
Nutrients; Apr 2020; 12(4). doi: 10.3390/nu12041067
S. Gachkar, R. Oelkrug, B. Herrmann, T.S. Scanlan, Q. Sun, H. Biebermann, C.S. Hoefig, L. Schomburg , J. Mittag.
N- and O-Acetylated 3-Iodothyronamines Have No Metabolic or Thermogenic Effects in Male Mice.
European Thyroid Journal; Feb 2020; 9(2):57-66. doi: 10.1159/000504887
S. Nock, K. Johann, L. Harder, E.K. Wirth, K. Renko, C. Höfig, V. Kracke, J. Hackler, B. Engelmann, M. Rauner, J. Köhrle, L. Schomburg, G. Homuth, U. Völker, G. Brabant, J. Mittag
CD5L constitutes a novel biomarker for integrated hepatic thyroid hormone action.
Thyroid; Mar 2020; 30 (6). doi: 10.1089/thy.2019.0635
C. Schwiebert, P. Kühnen, N.P. Becker, T. Welsink, T. Keller, W.B. Minich, S. Wiegand, L. Schomburg
Antagonistic Autoantibodies to Insulin-Like Growth Factor-1 Receptor Associate with Poor Physical Strength.
International Journal of Molecular Sciences; Jan 2020; 21(2). doi: 10.3390/ijms21020463
S. Mehl, Q. Sun, C.L. Görlich, J. Hackler, J.F. Kopp, K. Renko, J. Mittag, T. Schwerdtle, L. Schomburg
Cross-sectional analysis of trace element status in thyroid disease.
Journal of Trace Elements in Medicine and Biology; Mar 2020; 58, 126430. doi: 10.1016/j.jtemb.2019.126430
L. Schomburg
The other view: the trace element selenium as a micronutrient in thyroid disease, diabetes, and beyond.
Hormones (Athens); Mar 2020; 19(1):15-24. doi: 10.1007/s42000-019-00150-4
J. Hackler, M. Wisniewska, L. Greifenstein-Wiehe, W.B. Minich, M. Cremer, C. Bührer, L. Schomburg
Copper and selenium status as biomarkers of neonatal infections.
Journal of Trace Elements in Medicine and Biology; Mar 2020; 58, 126437. doi: 10.1016/j.jtemb.2019.126437
T. Bednarczuk, L. Schomburg
Challenges and perspectives of selenium supplementation in Graves' disease and orbitopathy.
Hormones (Athens); Mar 2020; 19(1):31-39. doi: 10.1007/s42000-019-00133-5
J. Seelig, R.A. Heller, J. Hackler, P. Haubruck, A. Moghaddam, B. Biglari, L. Schomburg
Selenium and copper status - potential signposts for neurological remission after traumatic spinal cord injury.
Journal of Trace Elements in Medicine and Biology; Jan 2020; 57, 126415. doi: 10.1016/j.jtemb.2019.126415
C. Neumann, J. Baesler, G. Steffen, M. M. Nicolai, T. Zubel, M. Aschner, A. Bürkle, A. Mangerich, T. Schwerdtle, J. Bornhorst
The role of poly(ADP-ribose) polymerases in manganese exposed Caenorhabditis elegans.
Journal of Trace Elements in Medicine and Biology; Jan 2020; 57:21-27. doi: 10.1016/j.jtemb.2019.09.001
S.M. Müler, C. Dawczynski, J. Wiest, S. Lorkowski, A.P. Kipp, T. Schwerdtle
Functional Biomarkers for the Selenium Status in a Human Nutritional Intervention Study.
Nutrients; Mar 2020; 12(3). doi: 10.3390/nu12030676
B. Witt, D. Schaumlöffel, T. Schwerdtle
Subcellular localization of copper – cellular bioimaging with focus on neurological disorders.
International Journal of Molecular Sciences; Mar 2020; 21, 2341. doi: 10.3390/ijms21072341
M. Braunstein, T. Kusmenkov, C. Zuck, M. Angstwurm, N. P. Becker, W. Böcker, L. Schomburg, V. Bogner-Flatz
Selenium and Selenoprotein P Deficiency Correlates with Complications and Adverse Outcome After Major Trauma.
Shock; Jan 2020. doi: 10.1097/SHK.0000000000001344
2019
S. C. Koeberle, A. Gollowitzer, J. Laoukili, O. Kranenburg, O. Werz, A. Koeberle, A. P. Kipp
Distinct and overlapping functions of glutathione peroxidases 1 and 2 in limiting NF-κB-driven inflammation through redox-active mechanisms.
Redox Biology; Nov 2019. doi: 10.1016/j.redox.2019.101388
J. Baudry, J. F. Kopp, H. Boeing, A. P. Kipp, T. Schwerdtle, M. B. Schulze
Changes of trace element status during aging: results of the EPIC-Potsdam cohort study.
European Journal of Nutrition; Nov 2019. doi: 10.1007/s00394-019-02143-w
K. Lossow, T. Schwerdtle, A. Kipp
Selenium and iodine - essential trace elements for the thyroid.
ERNÄHRUNGS UMSCHAU; Sep 2019; 66 (9): 175-180. doi: 10.4455/eu.2019.032
M. Schwarz, K. Lossow, J. F. Kopp, T. Schwerdtle, A. P. Kipp
Crosstalk of Nrf2 with the Trace Elements Selenium, Iron, Zinc, and Copper.
Nutrients; Sep 2019; 11: 2112. doi: 10.3390/nu11092112
W. Alker, T. Schwerdtle, L. Schomburg, H. Haase
A Zinpyr-1-based Fluorimetric Microassay for Free Zinc in Human Serum.
International Journal of Molecular Sciences; Aug 2019, 20 (16): 4006; doi: 10.3390/ijms20164006
L. Schomburg, M. Orho-Melander, J. Struck, A. Bergmann, O. Melander
Selenoprotein-P Deficiency Predicts Cardiovaskular Disease and Death.
Nutritients; Aug 2019;11 (8): 1852. doi: 10.3390/nu11081852
J. Baesler, J. F. Kopp, G. Pohl, M. Aschner, H. Haase, T. Schwerdtle, J. Bornhorst
Zn homeostasis in genetic models of Parkinson’s disease in Caenorhabditis elegans.
Journal of Trace Elements in Medicine and Biology; Sep 2019; 55: 44-49. doi: 10.1016/j.jtemb.2019.05.005
J. F. Kopp, S. M. Müller, G. Pohl, K. Lossow, A. P. Kipp, T. Schwerdtle
A quick and simple method for the determination of six trace elements in mammalian serum samples using ICP-MS/MS.
Journal of Trace Elements in Medicine and Biology; July 2019; 54: 221-225. doi: 10.1016/j.jtemb.2019.04.015
M. T. Jacques, J. Bornhorst, M. V. Soares, T. Schwerdtle, S. Garcia, D. S. Ávila.
Reprotoxicity of glyphosate-based formulation in Caenorhabditis elegans is not due to the active ingredient only.
Environmental Pollution; June 2019; 252(Pt B): 1854-1862. doi: 10.1016/j.envpol.2019.06.099
S. Wendt, L. Schomburg, W. Manzanares, C. Stoppe
Selenium in Cardiac Surgery.
Nutrition in Clinical Practice; June 2019. doi: 10.1002/ncp.10326
V. Fedirko, M. Jenab, C. Méplan, J. S. Jones, W. Zhu, L. Schomburg, A. Siddiq, S. Hybsier, K. Overvad,
A. Tjønneland, H. Omichessan, V. Perduca, M. C. Boutron-Ruault, T. Kühn, V. Katzke, K. Aleksandrova,
A. Trichopoulou, A. Karakatsani, A. Kotanidou, R. Tumino, S. Panico, G. Masala, C. Agnoli, A. Naccarati,
B. Bueno-de-Mesquita, R. Ch. Vermeulen, E. Weiderpass, G. Skeie, T. H. Nøst, L. Lujan-Barroso, J. R. Quirós,
J. M. Huerta, M. Rodríguez-Barranco, A. Barricarte, B. Gylling, S. Harlid, K. E. Bradbury, N. Wareham, K. T. Khaw,
M. Gunter, N. Murphy, H. Freisling, K. Tsilidis, D. Aune, E. Riboli, J. E. Hesketh, D. J. Hughes
Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status.
Nutrients; Apr 2019; 11 (4): 935. doi: 10.3390/nu11040935
I. Rohn, N. Kroepfl, J. Bornhorst, D. Kuehnelt, T. Schwerdtle
Side-Directed Transfer and Presystemic Metabolism of Selenoneine in a Human Intestinal Barrier Model.
Molecular Nutrition Food Research; Apr 2019. doi: 10.1002/mnfr.201900080
E. C. Kühn, A. Slagman, E. C. D. Kühn-Heid, J. Seelig, C. Schwiebert, W. B. Minich, C. Stoppe, M. Möckel, L. Schomburg
Circulating levels of selenium-binding protein 1 (SELENBP1) are associated with risk for major adverse cardiac events and death.
Journal of Trace Elements in Medicine and Biology; Mar 2019; 52: 247-253; doi: 10.1016/j.jtemb.2019.01.005
J. Bornhorst, E. J. Nustede, S. Fudickar
Mass-Surveilance of C. elegans - A Smartphone-based DIY Microscope and Machine Learning-based Approach for Worm Detection.
Sensors, Smartphone-Based Biosensing; Mar 2019; 19 (6): 1468. doi: 10.3390/s19061468
I. Rohn, S. Raschke, M. Aschner, S. Tuck, D. Kuehnelt, A. P. Kipp, T. Schwerdtle, J. Bornhorst
Treatment of Caenorhabditis elegans with Small Selenium Species Enhances Antioxidant Defense Systems.
Molecular Nutrution Food Research; Feb 2019; 63 (9): 1801304. doi: 10.1002/mnfr.201801304
Y. Wang, F. Zhao, E. Rijntjes, L. Wu, Q. Wu, J. Sui, Y. Liu, M. Zhang, M. He, P. Chen, S. Hu, P. Hou, L. Schomburg,
B. Shi
Role of Selenium Intake for Risk and Development of Hyperthyroidism.
The Journal of Clinical Endocrinology & Metabolism; Feb 2019; 104 (2): 568-580. doi: 10.1210/jc.2018-01713
L. Schomburg , O. Melander
Letter by Schomburg and Melander Regarding Article, "Selenoprotein P Promotes the Development of Pulmonary Arterial Hypertension: A Possible Novel Therapeutic Target.
Circulation; Jan 2019; 139: 722–723. doi: 10.1161/CIRCULATIONAHA.118.035782
R. A. Hellera, J. Seelig, T. Bock, P. Haubruck, P. A. Grützner, L. Schomburg, A. Moghaddam, B. Biglari
Relation of selenium status to neuro-regeneration after traumatic spinal cord injury.
Journal of Trace Elements in Medicine and Biology; Jan 2019; 51: 141-149. doi: 10.1016/j.jtemb.2018.10.006
2018
D. J. Hughes , T. Kunická, L. Schomburg, V Liška, N. Swan, P. Souček
Expression of Selenoprotein Genes and Association with Selenium Status in Colorectal Adenoma and Colorectal Cancer.
Nutrients; Nov 2018; 10 (11): 1812. doi: 10.3390/nu10111812
M. Maares, C. Keil, J. Koza, S. Straubing, T. Schwerdtle, H. Haase
In vitro studies on zinc binding and buffering by intestinal mucins.
International Journal of Molecular Sciences; Sep 2018; 19 (9): 2662. doi: 10.3390/ijms19092662
S. Meyer, M. Markova, G. Pohl, TA Marschall, O. Pivovarova, AFH Pfeiffer, T. Schwerdtle
Development, validation and application of an ICP-MS/MS method to quantify minerals and (ultra-)trace elements in human serum.
Journal of Trace Elements in Medicine and Biology; Sep 2018; 49: 157-163. doi: 10.1016/j.jtemb.2018.05.012
S. Trame, I. Wessels, H. Haase, L. Rink
A short 18 items food frequency questionnaire biochemically validated to estimate zinc status in humans.
Journal of Trace Elements in Medicine and Biology; Sep 2018; 49: 285-295. doi: 10.1016/j.jtemb.2018.02.020
M. Maares, C. Keil, S. Thomsen, D. Günzel, B. Wiesner, H. Haase
Characterization of Caco-2 cells stably expressing the protein-based zinc probe eCalwy-5 as a model system for investigating intestinal zinc transport.
Journal of Trace Elements in Medicine and Biology; Sep 2018; 49: 296-304. doi: 10.1016/j.jtemb.2018.01.004
J. Bornhorst, A. P. Kipp, H. Haase, S. Meyer, T. Schwerdtle
The crux of inept biomarkers for risks and benefits of trace elements.
Trends in Analytical Chemistry; July 2018; 104: 183-190. doi: 10.1016/j.trac.2017.11.007
W. Alker, H. Haase
Zinc and Sepsis.
Nutrients; July 2018, 10 (8): 976. doi: 10.3390/nu10080976
M. Maares, A. Duman, C. Keil, T. Schwerdtle, H. Haase
The impact of apical and basolateral albumin on intestinal zinc resorption in the Caco-2/HT-29-MTX co-culture model.
Metallomics; June 2018; 10(7): 979-991. doi: 10.1039/C8MT00064F
I. Rohn, TA Marschall, N. Kroepfl, KB Jensen, M. Aschner, S. Tuck, D. Kuehnelt, T. Schwerdtle, J. Bornhorst
Selenium species-dependent toxicity, bioavailability and metabolic transformations in Caenorhabditis elegans.
Metallomics; May 2018; 10(6): 818-827. doi: 10.1039/C8MT00066B
R. Muecke, O. Micke, L. Schomburg, J. Buentzel, K. Kisters, I. A. Adamietz, AKTE
Selenium in Radiation Oncology - 15 Years of Experiences in Germany.
Nutrients; Apr 2018; 10 (4), 483. doi: 10.3390/nu10040483
H. Haase
Innate Immune Cells Speak Manganese.
Immunity; Apr 2018; 48(4), 616-618. doi: 10.1016/j.immuni.2018.03.031
2017
S. Meyer, A. Lopez-Serrano, H. Mitze, N. Jakubowski, T. Schwerdtle
Single-cell analysis by ICP-MS/MS as fast tool for cellular bioavailability studies of arsenite (iAsIII).
Metallomics; Dec 2017, 10: 73-76. doi: 10.1039/C7MT00285H