Publications

Hagen, S., Mattay, D., Räuber, C., Müller, K.M. & Arndt, K.M. (2014). Characterization and inhibition of AF10-mediated interaction. J. Pept. Sci. 20(6), 385-397. Full text (pdf)

Azuma, Y., Kükenshöner, T., Ma, G., Yasunaga, J., Imanishi, M., Tanaka, G., Nakase, I., Maruno, T., Kobayashi, Y., Arndt, K.M.*, Matsuoka, M.* & Futaki S.* (2014). Controlling leucine-zipper partner recognition in cells through modification of a-g interactions. Chem. Commun. 50(48), 6364-6367. * corresponding authors Full text (pdf)

Kükenshöner, T., Hagemann, U.B., Wohlwend, D., Räuber, C., Baumann, T., Keller, S., Einsle, O., Müller, K.M., Arndt, K.M. (2014). Analysis of Selected and Designed Chimeric D- and L-α-Helix Assemblies. Biomacromolecules 15(9), 3296-3305. Full text (pdf)

Kükenshöner, T., Wohlwend, D., Niemöller, C., Dondapati, P., Speck, J., Adeniran, A.V., Nieth, A., Gerhardt, S., Einsle, O., Müller, K.M., Arndt, K.M. (2014). Improving coiled coil stability while maintaining specificity by a bacterial hitchhiker selection system. J. Struct. Biol. 186(3), 335-348. Full text (pdf)

Hagen, S., Baumann, T., Wagner, H.J., Morath, V., Kaufmann, B., Fischer, A., Bergmann, S., Schindler, P., Arndt, K.M.* & Müller, K.M.* (2014). Modular adeno-associated virus (rAAV) vectors used for cellular virus-directed enzyme prodrug therapy. Nature Scientific Reports 4, 3759. *corresponding authors Full text (pdf)

Baumann, T., Arndt, K.M. & Müller, K.M. (2013). Directional cloning of DNA fragments using deoxyinosine-containing oligonucleotides and endonuclease V. BMC Biotechnol. 13(1), 81. Full text (pdf)

Speck, J. ,Räuber, C., Kükenshöner, T., Niemöller, C., Mueller, K.J., Schleberger, P., Dondapati, P., Hecky, J., Arndt, K.M. & Müller, K.M. (2013). TAT hitchhiker selection expanded to folding helpers, multimeric interactions and combinations with protein fragment complementation. Protein Eng. Des. Sel. 26(3), 225-42. Full text (pdf)

Zuo, Z., Gandhi, N.S., Arndt, K.M. & Mancera, R.L. (2012). Free energy calculations of the interactions of c-Jun-based synthetic peptides with the c-Fos protein. Biopolymers 97(11), 899-909. Full text (pdf)

Speck, J., Hecky, J., Tam, H.K., Arndt, K.M., Einsle, O., Müller, K.M. (2012) Exploring the molecular linkage of protein stability traits for enzyme optimization by iterative truncation and evolution. Biochemistry 51(24), 4850-67. Full text (pdf)

Zhang, F., Müller, K.M., Woolley, G.A. & Arndt, K.M. (2012). Light-Controlled Gene Switches in Mammalian Cells. Methods Mol. Biol. 813, 195-210. Full text (pdf)

Müller, K.M. & Arndt, K.M. (2012). Standardization in Synthetic Biology. Methods Mol. Biol. 813, 23-43. Full text (pdf)

Speck, J., Arndt, K.M., Müller, K.M. (2011). Efficient phage display of intracellularly folded proteins mediated by the TAT pathway. Protein Eng. Des. Sel. 24(6), 473-484. Full text (pdf)

Speck, J., Stebel, S.C., Arndt, K.M., Müller, K.M. (2011). Nucleotide exchange and excision technology DNA shuffling and directed evolution. Methods Mol. Biol. 687, 333-344. Full text (pdf)

Zhang, F., Timm, K.A., Arndt, K.M. & Woolley, G.A. (2010). Photo-control of Coiled-coil Proteins in Living Cells. Angew. Chem. Int. Ed. 49(23): 3943-6. Full text (pdf)

Staab, P.R., Walossek, J., Nellessen, D., Grünberg, R., Arndt, K.M. & Müller, K.M. (2010). SynBioWave-a real-time communication platform for molecular and synthetic biology. Bioinformatics 26 (21), 2782-2783. Full text (pdf)

Mason, J.M., Hagemann, U.B. & Arndt, K.M. (2009). Role of Hydrophobic and Electrostatic Interactions in Coiled Coil Stability and Specificity. Biochemistry 48(43): 10380-10388. Full text (pdf)

Mason, J.M., Müller, K.M. & Arndt, K.M. (2009). Peptides tailored to interfere with protein interaction and function. Chemistry Today 27(): 47-50. Full text (pdf)

Jouaux, E.M., Timm, B.B., Arndt, K.M.* & Exner, T.E.* (2009). Improving the Interaction of Myc-Interfering Peptides with Myc Using Molecular Dynamics Simulations. J. Pept. Sci. 15(1): 5-15. (*corresponding authors) Full text (pdf)

Gaida, A., Hagemann, U.B., Mattay, D., Räuber, C., Müller, K.M. & Arndt, K.M. (2009). Identification of peptides interfering with protein-protein interaction. Methods Mol. Biol., Vol. 535, 263-291. Full text (PDF)

Mason, J.M., Müller, K.M. & Arndt, K.M. (2008). iPEP: Peptides designed and selected for interfering with protein interaction and function. Biochem Soc Trans. 36(6): 1442-1447. Full text (PDF)

Hagemann, U.B., Mason, J.M., Müller, K.M. & Arndt, K.M. (2008). Selectional and mutational scope of peptides sequestering the c-Fos coiled coil domain. J. Mol. Biol. 381(1):73-88. Full text (PDF)

Jouaux, E.M., Schmidtkunz, K., Müller, K.M. & Arndt, K.M. (2008). Targeting the c-Myc coiled coil with interfering peptides to inhibit DNA binding. J. Pept. Sci. 14(9):1022-31. Full text (PDF)

Arndt, K.M., Boldt, J., Müller, K.M., Müller, O. (2008). Von der Manipulation zur Kreation - Ethische und ontologische Aspekte der synthetischen Biologie. Jahrbuch für Wissenschaft und Ethik, De Gruyter, Berlin, New York 2008, Vol. 13, pp. 153-180.

Willemsen, T.*, Hagemann, U.B.*, Jouaux, E.M.*, Stebel, S.C., Mason, J.M., Müller, K.M.& Arndt, K.M. (2008). Protein Engineering. Protein and Cell Biomethods Handbook, 2nd edition, 587-629. (*authors contributed equally) Full text (pdf)

Stebel, S.C., Gaida, A., Arndt, K.M. & Müller, K.M. (2008). Directed Protein Evolution. Molecular Biomethods Handbook, 2nd edition, 631-656. Full text (pdf)

Arndt, K.M. (2008). Book Review: Handbook of Proteins - Structure, Function and Methods. Edited by Michael M. Cox and George N. Phillips, Jr. ChemBiochem 9: 2005-2007. Fulll text (PDF)

Mason, J.M., Hagemann, U.B. & Arndt, K.M. (2007). Improved Stability of the Jun-Fos Activator Protein-1 Coiled Coild Motif: A Stopped-flow Circular Dichroism Kinetic Analysis. J. Biol. Chem. 282(32):23015-24. Full text (PDF)

Mason, J.M., Müller, K.M. & Arndt, K.M. (2007). Positive aspects of negative design: Simultaneous Selection of Specificity and Interaction Stability. Biochemistry 46(16), 4804-14. Full text (pdf)

Mason, J.M., Müller, K.M. &Arndt, K.M. (2007). Considerations in the design and optimization of Coiled coils structures. Methods Mol. Biol. 352, 35-70. Full text (PDF)

Stebel, S.C., Arndt, K.M. & Müller, K.M. (2007). Versatile DNA fragmentation and directed evolution with nucleotide exchange and excision technology. Methods Mol. Biol. 352, 167-190. Full text (PDF)

Hecky, J., Mason, J.M., Arndt, K.M. & Müller, K.M. (2007). A General Method of Terminal Truncation, Evolution, and Re-Elongation to Generate Enzymes of Enhanced Stability. Methods Mol. Biol. 352, 275-304. Full text (PDF)

Arndt, K.M. (2007). Book Review: Methods in Molecular Biology, Vol. 340: Protein Design: Methods and Applications. Edited by Raphael Guerois and Manuela López de la Paz." ChemBiochem 8(4); 459-460. Full text (PDF)

Mason, J.M., Schmitz, M.A., Müller, K.M. & Arndt, K.M. (2006). Semirational design of Jun-Fos coiled coils with increased affinity: Universal implications for leucine zipper prediction and design. Proc. Natl. Acad. Sci. USA 103(24), 8989-8994. Full text (PDF)

Müller, K.M., Stebel, S.C., Knall, S., Zipf, G., Bernauer, H.S. & Arndt, K.M. (2005). Nucleotide Exchange and Excision Technology (NExT) DNA shuffling: A robust method for DNA fragmentation and directed evolution. Nucleic Acids Research 33(13); e117. Full text (PDF)

Mason, J.M. & Arndt, K.M. (2004). Coiled coil domains: stability, specificity, and biological implications. ChemBiochem 5(2); 170-6. Full text (PDF)

Jouaux, E.M., Willemsen, T. & Arndt, K.M. (2004). Der richtige Dreh - Coiled coils auf dem Weg zur Anwendung. BioForum 10; 48-49. Full text (PDF)

Arndt, K.M., Pelletier, J.N., Müller, K.M.,Plückthun, A. & Alber, T. (2002). Comparison of in-vivo selection and rational design of heterodimeric coiled coils. Structure (Camb) 10(9); 1235-48. Full text (PDF)

Arndt, K.M., Müller, K.M. & Plückthun, A. (2001). Helix-stabilized Fv (hsFv) antibody fragments: Substituting the constant domains of a Fab Fragment for a heterodimerc coiled-coil domain. Journal of Molecular Biology 312(1), 221-8. Full text (PDF)

Arndt, K.M., Pelletier, J.N., Müller, K.M., Alber, T., Michnick, S. W. & Plückthun, A. (2000). A heterodimerc coiled-coil peptide pair selected in vivo from a designed library-versus-library ensemble. Journal of Molecular Biology, 295(3), 627-39. Full text (PDF)

Arndt, K.M., Jung, S., Krebber, C. & Plückthun, A. (2000). Selectively-infective phage technology. Methods in Enzymology, “Chimeric Genes and Proteins”, Eds. J. Abelson and M.I. Simon, 328, 364-88. Full text (PDF)

Müller, K.M., Arndt, K.M. & Alber, T. (2000). Protein fusions to coiled-coil domains. Methods in Enzymology, “Chimeric Genes and Proteins”, Eds. J. Abelson and M.I. Simon, 328, 261-82. Full text (PDF)

Arndt, K.M. (2000). Heterodimeric Coiled-coil Domains - Design, Selection, Analysis and Application. Dissertation, University of Zürich, Switzerland and University of California, Berkeley, CA, USA.

Pelletier, J.N., Arndt, K.M., Plückthun, A. & Michnick, S.W. (1999). An in vivo library-versus-library selection of optimized protein-protein interactions. Nature Biotechnology 17(7), 683-90. Full text (PDF)

Jung, S., Arndt, K.M., Müller, K.M. & Plückthun, A. (1999). Selectively-infective phage (SIP) selection technology: scope and limitations. Journal of Immunological Methods, 231(1-2), 93-104. Full text (PDF)

Arndt, K.M., Müller, K.M. & Plückthun, A. (1998). Factors influencing the dimer to monomer transition of an antibody single-chain Fv fragment. Biochemistry 37(37), 12918-26. Full text (PDF)

Müller, K.M., Arndt, K.M. & Plückthun, A. (1998). Model and simulation of multivalent binding to fixed ligands. Analytical Biochemistry 261(2), 149-58. Full text (PDF)

Müller, K.M., Arndt, K.M. & Plückthun, A. (1998). A dimeric bispecific miniantibody combines two specificities with avidity. FEBS Letters 432(1-2), 45-9. Full text (PDF)

Müller, K.M., Arndt, K.M., Bauer, K. & Plückthun, A. (1998). Tandem immobilized metal-ion affinity chromatography/immunoaffinity purification of His-tagged proteins - evaluation of two anti-His-tag monoclonal antibodies. Analytical Biochemistry 259(1), 54-61. Full text (PDF)

Müller, K.M., Arndt, K.M., Strittmatter, W. & Plückthun, A. (1998). The first constant domain (CH1 and CL) of an antibody used as heterodimerization domain for bispecific miniantibodies. FEBS Letters 422(2), 259-64. Full text (PDF)

Arndt, K.M. (1995). Characterization of novel heteromerization and oligomerization domains for miniantibodies (original title: Untersuchung neuartiger Heteromerisierungs- und Oligomerisierungsdomänen für Miniantikörper). Masters thesis (Diplomarbeit), University of Zürich, Switzerland.

Patents

Arndt, K.M., Pelletier, J.N., Plückthun, A. & Michnick, S.W. (2005). In vivo library-versus-library selection of optimized protein-protein interactions. Patent US 6,897,017; CA 2,377,573; EP 1198586; AU 200060549; WO 01/00866.

Arndt, K.M., Müller, K.M., Pelletier, J.N. & Plückthun, A. (2001). Heteroassociating coiled-coil peptides and screening method therefore. Patent CA 2,377,513; EP1194539; WO 01/00814.

Oral Presentations

scheduled: "Interfering Peptides Targeting Protein-protein Interactions"; IBC's 15th Annual TIDES: Oligonucleotide and Peptide Therapeutics - From Research through Commercialization; Boston, MA, U.S.A.; May 12-15, 2013.

"iPEP - Interfering Peptides Targeting Protein-Protein Interactions"; CHI PepTalk: Recombinant Protein Therapeutics; Palm Springs, CA, U.S.A.; January 21-25, 2013.

"iPEP – Interfering Peptides Targeting Protein-Protein Interactions”; IBC Conference Next Generation Protein Therapeutics Summit; San Francisco, CA, U.S.A.; June 25-27, 2012.

"Targeting Protein-Protein Interactions with Interfering Peptides"; CRC 850: Control of Cell Motility in Morphogenesis, Cancer Invasion and Metastasis; University of Freiburg, Germany; February 24, 2012.

"Targeting protein-protein interactions with photo-switchable peptides"; PEGS Europe Protein & Antibody Engineering Summit; Hannover, Germany, October 11-13, 2011.

"Controlling protein-protein interaction with photo-switchable peptides"; 7^th Annual R&D of Novel Protein Therapeutics, part of the Bioanalytical Congress Conference, Informa Life Science, Berlin, Germany, September 26-29, 2011.

"Targeting Protein-Protein Interactions with Interfering Peptides"; BioProcessing, Biologics & Biotherapeutics Congress; Edinburgh, UK, July 20-21, 2011.

“Controlling Protein-Protein Interactions with Interfering Peptides”; IBC Conference Next Generation Protein Therapeutics; San Francisco, CA, USA, June 20-22, 2011.

“iPEP – Peptides Interfering with Tumor Associated Proteins”; SINOGFOS – Sino-German Frontiers of Science Symposium, Alexander von Humboldt Foundation; Berlin, Germany, April 27-30, 2011.

“Targeting Extended Protein Interaction Surfaces with Photo-Switchable Peptides”; CHI PepTalk: Recombinant Protein Therapeutics; San Diego, CA, USA, January 10-11, 2011.

"Photo-Switchable Peptides Targeting Extended Protein Interaction Surfaces"; ESF-EMBO Symposium 'Molecular Perspectives on Protein-Protein Interactions', Sant Feliu de Guixols, Spain, November 14-19, 2010.

"Photo-Switchable Peptides Targeting Extended Protein Interaction Surfaces"; IBC’s Next Generation Protein Therapeutics / Biologics Summit, San Francisco, CA, U.S.A., June 21-23, 2010.

"Development of Photo-switchable Peptides to Inhibit Protein-Protein Interactions"; The Peptide Conference 2010; Hinxton, UK, March 30-31, 2010.

“Design and Application of Interfering Peptides (iPEP) for Manipulation of Protein-Protein Interactions”; Department of Medicine, University of Düsseldorf, Düsseldorf, Germany, October 10, 2009.

"Selection Strategies for the Development of Peptides Targeting Protein-Protein Interactions", PEGS Europe: Next Generation Technologies for Protein Expression conference, Hannover, Germany, October 7-8, 2009.

"Selection Strategies for the Development of Peptides Targeting Protein-Protein Interactions", Peptides Europe, Berlin, Gemany, September 17-18, 2009.

"Turning Interactors into Inhibitors – Unwinding Coiled Coil Specificity and Stability", Alpbach Workshop on 'Coiled-Coils, Collagen and Co-Proteins'; Alpbach, Austria, September 6-12, 2009.

"Development of Photo-switchable Interfering Peptides to Manipulate Protein Networks", European Systems & Synthetic Biology-2009 (ESSB-2009) Meeting; Evry, France, September 14-15, 2009.

"Design und Selektion von Peptiden zur Inhibition onkogener Protein-Protein Wechselwirkungen", Department of Life Sciences I, University of Halle, Germany, May 4, 2009.

"Tailoring Peptides to Inhibit Oncogenic Protein Interaction and Function", Department of Medicine, University of Göttingen, Germany, April 30, 2009.

"Novel approaches to perturb protein-protein interactions"; invited talk in the session "Novel approaches to perturb protein-protein interactions"; Annual Meeting of the Society of Biomolecular Sciences (SBS), Lille, France, April 27-30, 2009.

“Synthetic Peptides Targeting Protein-Interactions”, Applied Industrial Synthetic Biology; Freiburg, Germany, April 16-17, 2009.

"Peptides Tailored to Interfere with Protein Interaction and Function", Informa Life Sciences 8th European EuroTIDES conference, Düsseldorf, Germany, December 2-3, 2008.

"Engineering Peptides for Interfering with Protein Interaction and Function", University of Potsdam, Golm, Germany, November 7, 2008.

"Engineering Peptides for Targeting Protein-Protein Interactions with High Affinity and Specificity", Genentech, South San Francisco, CA, USA, August 25, 2008.

"iPEP – Peptides designed and selected for interfering with protein interaction and function", 2nd International Conference on Molecular Perspectives on Protein-Protein Interactions, Dubrovnik, June 27-July 1, 2008.

"Designer-Peptide zur Inhibition onkogener Protein-Protein Wechselwirkungen", Innere Medizin I, Hepatologie und Onkologie, Universitätsklinikum Freiburg, Germany, April 29, 2008.

"iPEP – Peptides Designed and Selected for Interfering with Protein Interaction and Function", Georg-Speyer-Haus, Frankfurt, February 21, 2008.

"Targeting and Inhibiting Oncogenic Transcription Factors with D- and L-Peptides", CHI PepTalk: Peptide and Protein-based Therapeutics – Pioneering New Frontiers, San Diego, CA, USA, January 8, 2008.

"Targeting and Inhibiting Oncogenic Transcription Factors with D- and L-Peptides", GBM Fall Meeting – Molecular Life Sciences 2007, Hamburg, September 19, 2007.

"Targeting and Inhibiting Oncogenic Transcription Factors with D- and L-Peptides", Department of Chemistry, University of Toronto, Toronto, Canada, July 26, 2007.

"Peptides targeted against oncogenic transcription factors", European Bioperspectives 2007, Cologne, June 1, 2007.

"Tailored peptides to interfere with coiled-coil proteins", MorphoSys, Munich, February 7, 2007.

"Engineering Protein Interactions to Interfere with Gene Expression", IBC's 2nd Annual International Conference on 'Protein Engineering for Biotherapeutics', San Diego, CA, USA, December 12-14, 2006.

"Coiled-Coil Peptides as Tool to Understand And Manipulate Cellular Protein Networks", Medizinische Fakultät, Universität Bonn, Germany, October 30, 2006.

"Coiled-Coil Peptides as Tools to Understand And Manipulate Protein-Protein Interactions", Innere Medizin I, Hepatologie und Onkologie, Universitätsklinikum Freiburg, Germany, October 10, 2006.

"Interfering Coiled Coils – A Tool To Understand And Manipulate Protein-Protein Interactions", Medizinische Fakultät, Universität Göttingen, Germany, November 29, 2005.

"Coiled Coils – A Tool To Understand And Interfere With Protein-Protein Interaction", Summerschool University of Frankfurt, Kleinwalsertal, Austria, September 20, 2005.

"Design and Selection of Interfering Coiled Coils", Dept. of Biochemical Sciences, University of Rome "La Sapienza", Rome, Italy, June 20, 2005.

"Design and Selection of Peptides Interfering with Protein-Protein Interaction", Fachbereich Chemie Universität Konstanz, Konstanz, Germany, April 20, 2005.

"Design of Coiled Coils for Biological and Medical Applications", Max Planck Institute for Developmental Biology, Tübingen, Germany, July 20, 2004.

"Coiled Coils – Comparison of In Vivo Selection and Rational Design", Symposium des Graduiertenkollegs 805: Protein-Protein Interaktionen in der Siugnaltransduktion, Regensberg, Germany, November 7-8, 2003.

"Heterodimeric Coiled Coils Selected in vivo and Applied for Fv Fragment Stabilization", Genentech Inc., South San Francisco, CA, U.S.A., December 3, 1999.

"An in vivo Library-versus-Library Selection of Optimized Protein-Protein Interactions", conference Molecular Library Technologies at the Millennium, San Francisco, CA, U.S.A., October 24-26, 1999.

Poster Presentations

scheduled: Behrsing, O., Hagen, S. Hoffmann, S., Kükenshöner, T., Matyssek, F., Müller, K.M. & Arndt, K.M. "Interfering Peptides (iPEP) Targeting Cancer Proteins"; SINOGFOS – Sino-German Frontiers of Science Symposium, Alexander von Humboldt Foundation; Merseburg, Germany, May, 23-26, 2013.

Kükenshöner, T., Azuma, Y., Niemöller, J.C., Speck, J., Müller, K.M. & Arndt, K.M. "Improving Solubility, Specificity and Stability of Inhibitory Peptides"; CRC 850: Control of Cell Motility in Morphogenesis, Cancer Invasion and Metastasis; University of Freiburg, Germany; February 20-22, 2013.

Hagemann, U.B., Hagen, S., Hajri, A., Kükenshöner, T., Mason, J.M., Mattay, D., Niemöller, C., Räuber, C. Speck, J., Timm, K. Zhang, F. Müller, K.M. & Arndt, K.M. “Training Proteins and Peptides for Attacking Cancerous Proteins”; SINOGFOS – Sino-German Frontiers of Science Symposium, Alexander von Humboldt Foundation; Nanjing, China, April 26-29, 2012.

Räuber, C., Speck, J., Freeland, M.M., Majumdar S., Mattay, D., Müller, K.M. & Arndt, K.M. “Selection of interfering peptides targeting the leukemia-relevant AF10/hDOT1L interaction”; MipTec, Basel, Switzerland, September 20-24, 2010.

Räuber, C., Speck, J., Freeland, M.M., Majumdar S., Mattay, D., Müller, K.M. & Arndt, K.M. “Analyzing and blocking cancerous AF10 signaling by designed and selected interfering peptides (iPEP)“; BIOSS Symposium „Signalling meets Synthetic Biology“, Freiburg, Germany, September 23-25, 2010.

Arndt, K.M., Mason, J.M. "Engineering stable and specific protein:protein interactions and understanding their mechanism of action", poster P003; Experimental Approaches to Protein:Protein Interactions, Biochemical Society: Advancing Molecular Bioscience, University of Sheffield, UK, January 11-12, 2010.

Kükenshöner, T., Hagemann, U., Niemöller, J.C., Müller, K.M., Arndt, K.M. "Packing between Left-Handed and Right-Handed Helices: Coiled Coils?", Alpbach Workshop on 'Coiled-Coils, Collagen and Co-Proteins'; Alpbach, Austria, September 6-12, 2009.

Timm, K.A., Zhang, F., Hagemann, U., Müller, K.M., Woolley, G.A., Arndt, K.M. "Design of Molecular Recognition Elements and Switches Based on Small Helical Motifs", Scientific Advisory Board Meeting, Center for Biological Signaling Studies (bioss), Lenzkirch-Saig, June 30-July 1, 2009.

Müller, K.M., Hautzinger, D., Busacker, M., Gawlik, R., Jägle, S., Kilb, N., Kneib, M., Mappes, P., Pieper, K., Weber, S., Speck, J., Swamy, M., Santer, S., Schamel, W., Korvink, J., Arndt, K.M. "Synthetic Receptor Signaling", Scientific Advisory Board Meeting, Center for Biological Signaling Studies (bioss), Lenzkirch-Saig, June 30-July 1, 2009.

Speck, J., Baumann, T., Hecky, J., Mueller, K., Arndt, K.M. & Müller, K.M. "Optimization of a Split Enzyme as Signaling Reporter by Directed Evolution in Combination with a Perturbation-Optimization Strategy and Folding Selection", Scientific Advisory Board Meeting, Center for Biological Signaling Studies (bioss), Lenzkirch-Saig, June 30-July 1, 2009.

Mason, J.M., Hagemann, U.B., Müller, K.M. & Arndt, K.M. "Perturbing Protein-Protein Interactions with Interfering Peptides (iPEP): Co-evolution of Affinity and Specificty", VIII European Symposium of the Protein Society, Zurich, Switzerland, June 14-18.

Speck, J., Mueller, K., Hecky, J., Baumann, T., Arndt, K.M.,& Müller, K.M. "Directed Evolution of Enzymes and Split Proteins by a Perturbation-Optimization Strategy and Folding Selection", VIII European Symposium of the Protein Society, Zurich, Switzerland, June 14-18.

Freeland, M.M., Räuber, C. & Arndt, K.M. "Peptide inhibition of AF10/hDot1L coiled coil interactions", The Southern California Conference for Undergraduate Research (SCCUR), California State Polytechnic University, Pomona, CA, U.S.A., November 22, 2008.

Pieper, K., Jägle, S., Weber, S., Kilb, N., Kneib, M., Gawlik, R., Busacker, M., Mappes, P., Hautzinger, D., Speck, J., Swamy, M., Schamel, W., Arndt, K.M. & Müller, K.M., "Modular Synthetic Receptor System", international Genetically Engineered Machine Competition (iGEM), MIT, Cambridge, MA, USA, November 7-10, 2008.

Mattay, D., Räuber, C., Müller, K.M. & Arndt, K.M. "Targeting the AF10 coiled-coil domain in acute myeloid and lymphoblastic leukemia" 11th Annual MipTec Conference, the leading European event for Drug Discovery, Basel, Switzerland, October 14-16, 2008.

Freeland, M.M., Räuber, C. & Arndt, K.M. "Peptide inhibition of AF10/hDot1L coiled coil interactions", American Chemical Society's Annual Conference, Philadelphia, PA, U.S.A., August, 2008.

Gruber, C., Hermida-Aponte, D., Maier, N., Mauler, M., Busacker, M., Mappes, P., Arndt, K.M. & Müller, K.M. "Integrated Sensor-Executor Proteins and Molecular Switches – a Biobrick Compatible Strategy for Fusion Proteins", international Genetically Engineered Machine Competition (iGEM), MIT, Cambridge, MA, USA, November 2-6, 2007.

Mattay, D. Willemsen, T. & Arndt, K.M. "Design, selection and characterization of a peptide targeting the leukemia-relevant protein AF10", XXIII Symposium der IACRLRD: From Molecular Pathogenesis to Targeted Therapy in Leukemia and Solid Tumors, Freiburg, Germany, September 7-11, 2007.

Mattay, D., Willemsen, T. & Arndt, K.M. "Targeting the coiled-coil domain of the leukemia-relevant protein AF10". IBC conference: Drug Discovery and Development of Innovative Therapeutics", Boston, MA, USA, August 6-9, 2007.

Mason, J.M., Hagemann, U.B., Müller, K.M. & Arndt, K.M. "Targeting and Inhibiting Oncogenic Transcription Factor AP-1 with D- and L-Peptides", 21st Symposium of the Protein Society: Proteins: From Birth to Death", Boston, MA, USA, July 21-25, 2007; Poster 410.

Hecky, J., Stebel, S.C., Willemsen, T., Arndt, K.M. & Müller, K.M. "Engineering and Directed Evolution Techniques for Tailored Proteins: NExT DNA Shuffling, Structural Perturbations, and Split Enzymes", Synthetic Biology 3.0, Zurich, Switzerland, June 24-26, 2007.

Hagemann, U.B., Nordhues, A. & Arndt, K.M. "Generation of Chimeric D-/L-Coiled Coils by Phage Display" VIIth European Symposium of the Protein Society, Stockholm, Sweden. May 12-16, 2007; Poster II-5.

Mason, J.M., Hagemann, U.B., Müller, K.M. & Arndt, K.M. "Positive Aspects of Negative Design: Simultaneous Selection of Specificity and Interaction Stability" VIIth European Symposium of the Protein Society, Stockholm, Sweden. May 12-16, 2007; Poster III-1.

Müller, K.M., Stebel, S.C., Hecky, J. & Arndt, K.M. "Exploiting trait linkage in directed evolution: Compensatory activity selection of an enzyme at 37°C yields stabilization above 70°C." VIIth European Symposium of the Protein Society, Stockholm, Sweden. May 12-16, 2007; Poster II-103.

Rabenstein, H., Mason, J.M., Hagemann, U.B., Müller, K.M. & Arndt, K.M. "Design, Selection and Characterization of Peptidic Inhibitors of AP-1" Conference 'Proteins: Structure, Function and Assembly in Health and Disease', Rotorua, New Zealand, February 12-16, 2007.

Willemsen, T. & Arndt, K.M. "Specific inhibition of the coiled-coil domain in the leukemia relevant protein AF10". Conference 'Genomics And Cancer 2006', Heidelberg, Germany, September 13-16, 2006.

Stebel, S.C., Knall, S., Arndt, K.M. & Müller, K.M. "Nucleotide Exchange and Excision Technology (NeXT) DNA shuffling: computable, robust and fast DNA fragmentation", Conference 'Protein Design and Evolution for Biocatalysis', Greifswald, Germany, Aug. 30-Sept. 1, 2006.

Hagemann, U.B., Mason, J.M. & Arndt, K.M. "Targeting Chimeric D-/L-Coiled Coil Interactions with Phage Display for Therapeutical Applications". 20th Annual Symposium of The Protein Society, San Diego, CA, USA, August 5-9, 2006.

Mason, J.M., Hagemann U.B., Müller, K.M. & Arndt K.M. "Peptides Interfering with Protein Function". MipTec Conference, Basel, Switzerland. May 8-11, 2006.

Mason, J.M., Schmitz, M.A., Müller, K.M. & Arndt, K.M. "Peptides Interfering with Protein Function." Mechanismen of Tumour Invasion and Metastasis Workshop, Glasgow, Scotland. March 19-21, 2006. Poster 31.

Jouaux, E.M., Exner, T. & Arndt, K.M. "Targeting against Myc:Max coiled coil domain for specific inhibition". Katzir Conference on Molecular Perspectives on Protein-Protein Interactions, Eilat, Israel. November 6-10, 2005; Poster 72.

Mason, J.M. & Arndt, K.M. "Design, selection, and charaterization of AP-1 Jun-Fos leucine zipper varients with increased affinity and specificity." Viertes Emmy Noether-Jahrestreffen, Potsdam, Germany, July 15-17, 2005.

Müller, K.M., Stebel, S.C., Knall, S., Zipf, G., Arndt, K.M. & Bernauer, H.S. "Nucleotide Exchange and Excision Technology (NExT) DNA shuffling". VBU Technologieforum Weiße Biotechnologie, Frankfurt/Main, Germany, June 2-4, 2005.

Hagemann U. & Arndt, K.M. "Aiming at the Mirror: Generation of chimeric D-/L-coiled coils". Bioperspectives, Wiesbaden, Germany. May 10-12, 2005.

Jouaux, E.M. & Arndt, K.M. "Design of a specific inhibitor of Myc:Max coiled coil domain". Bioperspectives, Wiesbaden, Germany. May 10-12, 2005; Poster 14.4.

Willemsen, T. & Arndt, K.M. "Targeting Coiled-Coil Domains of Leukemia Relevant Proteins for Specific Inhibition". Bioperspectives, Wiesbaden, Germany. May 10-12, 2005.

Stebel, S.C., Speck, A.J., Knall, S., Zipf, G., Arndt, K.M., Bernauer, H.S. & Müller, K.M. "A predictive method for DNA fragmentation - Nucleotide Exchange and Excision Technology (NExT) DNA shuffling". Bioperspectives, Wiesbaden, Germany. May 10-12, 2005.

Mason, J.M. & Arndt, K.M. "Design, selection, and charaterization of AP-1 Jun-Fos leucine zipper varients with increased affinity and specificity." VIth European Symposium of the Protein Society, Barcelona, Spain. April 30-Mai 4, 2005; Poster 05-105.

Jouaux, E.M., Hagemann, U., Willemsen, T., Müller, K.M. & Arndt, K.M. "Design and selection of peptides interfering with coiled coil formation". VIth European Symposium of the Protein Society, Barcelona, Spain. April 30-Mai 4, 2005; Poster 08-025.

Mason, J.M. & Arndt, K.M. "Peptides targeted against Activator Protein-1 generate complexes with increased affinity and specificity over the wild-type". Protein Sorting International Symposium, Freiburg, Germany. March 6-8, 2005.

Jouaux, E.M., Hagemann, U., Willemsen, T., Müller, K.M. & Arndt, K.M. "Targeting coiled coil domains for specific inhibition." Protein Sorting International Symposium, Freiburg, Germany. March 6-8, 2005; Poster 3.

Hagemann, U., Jouaux, E.M., Mason, J.M., Müller, K.M. & Arndt, K.M. "Defining Rules for Specific Inhibition of Coiled Coil Proteins". INPEC Meeting, Brunnen, Switzerland, September 22-25, 2004; Poster 16.

Müller, K.M., Stebel, S.C., Knall, S., Zipf, G., Arndt, K.M. & Bernauer, H.S. "Nucleotid Exchange and Excision Technology (NExT) DNA shuffling: a robust method for DNA fragmentation and directed evolution". INPEC Meeting, Brunnen, Switzerland, September 22-25, 2004; Poster 17.

Hagemann, U., Jouaux, E.M., Mason, J.M., Willemsen, T., Schmidtkunz, K., Müller, K.M. & Arndt, K.M. "Design of Coiled Coils for Biological and Medical Applications". Drittes Emmy Noether-Jahrestreffen, Potsdam, Germany, July 30 - August 1, 2004.

Arndt, K.M., Pelletier, J.N., Müller, K.M., Michnick, S.W., Alber, T., Plückthun, A. "An In-vivo Library-versus-Library Selection of Heterodimeric Coiled Coil Pairs". Molecular Library Technologies at the Millennium, San Francisco, CA, U.S.A., October 24-26, 1999.

Arndt, K.M., Pelletier, J.N., Müller, K.M., Michnick, S.W., Alber, T., Plückthun, A. "In-vivo Selection, Characterization and Application of Heterodimeric Coiled Coil". The Protein Society, third European Symposium, Garmisch-Partenkirchen, Germany, Sept. 19-22, 1999; Protein Science 8, suppl. 2, p. 56, poster 124, 1999.

Arndt, K.M., Pelletier, J.N., Müller, K.M., Alber, T., Michnick, S.W., Plückthun, A. "A Heterodimeric Coiled-Coil Pair Simultaneously Selected in vivo from Two Designed Libraries". The Protein Society, thirteenth symposium, Boston, MA, U.S.A., July 24-28, 1999; Protein Science 8, suppl. 1, p. 83, poster 156-T, 1999.

Müller, K.M., Arndt, K.M. and Alber, T. "A Library of a Structured Enzyme Surface to Probe Binding Capability and Mutational Flexibility". The Protein Society, thirteenth symposium, Boston, MA, U.S.A., July 24-28, 1999; Protein Science 8, suppl. 1, p. 83, poster 156-T, 1999.

Arndt, K.M.., Müller, K.M. and Plückthun, A. "Factors Influencing the Dimer to Monomer Transition of an Antibody Single-Chain Fv Fragment". Antibody Engineering, 9th Annual International Conference, Coronado, CA, U.S.A., December 1-3, 1998.

Arndt, K.M., Pelletier, J.N., Müller, K.M., Michnick, S.W. and Plückthun, A. "Simultaneous Selection of Two Interacting Coiled-Coil Peptide Libraries Using an in-vivo Protein Complementation Assay". The Protein Society, twelfth symposium, San Diego, CA, U.S.A., July 25-29, 1998; Protein Science 7, suppl. 1, p. 89, poster 204-S, 1998.

Pelletier, J.N., Arndt, K.M., Plückthun and A. Michnick, S.W. "An in-vivo competition strategy for the selection of optimized protein-protein interactions." The Protein Society, twelfth symposium, San Diego, CA, U.S.A., July 25-29, 1998; Protein Science 7, suppl. 1, p. 93, poster 225-S, 1998.

Müller, K.M., Arndt, K.M. and Plückthun, A. "Model and Simulation of Multivalent Binding to Fixed Ligands". The Protein Society, twelfth symposium, San Diego, CA, U.S.A., July 25-29, 1998; Protein Science 7, suppl. 1, p. 156, poster 603-S, 1998.

Arndt, K.M., Müller K.M. and Plückthun A. "In-vivo Selection of Interacting Peptide Libraries by Selectively-Infective Phages". The 17th International Congress of Biochemistry and Molecular Biology, and Satellite Meeting Molecular Mimicry, San Francisco, CA, U.S.A.,

August 22-29, 1997; FASEB Journal 11(9), p. A836, poster M38; p. A1327, poster 2744, 1997.

Müller K.M., Arndt K.M. and Plückthun A. "Design and Evaluation of Bispecific Miniantibodies". The 17th International Congress of Biochemistry and Molecular Biology, and Satellite Meeting Molecular Mimicry, San Francisco, CA, U.S.A., August 22-29, 1997; FASEB 11(9), p. A836 poster M37, 1997.

Arndt K.M., Müller K.M. and Plückthun A. "Evolutionary in vivo-Selection of Heteromerization Domains - Simultaneous Selection of Two Interacting Peptide Libraries". The 1997 Miami Nature Biotechnology Winter Symposium: Biomolecular Design, Form and Function, poster No. M47, Ft. Lauderdale, FL 33316, U.S.A. February 1-5, 1997.

Müller K.M., Arndt K.M. and Plückthun A. "The First Constant Domains of an Antibody (CH1 and CL) Used for Heterodimerization in Bispecific Miniantibodies". The 1997 Miami Nature Biotechnology Winter Symposium: Biomolecular Design, Form and Function, poster No. T47, Ft. Lauderdale, FL 33316, U.S.A., February 1-5, 1997.

Müller K.M., Arndt K.M., Strittmatter W. and Plückthun A. "A Dimeric Bispecific (DiBi) Mini

antibody for Targeted Cytotoxicity". GBF-Symposium: Antibody Technology and Applications in Health and Environment, poster No. 52, Braunschweig, Germany, September 6-10, 1996.